Four insomniac med school students are lured into a neuroscience experiment that spirals out of control and must find a way out before it's too late.

讲述了科研队在考察途中遭遇飞机失事坠入无人冰山，种群研究之旅变亡命之旅。科研小队幸存者宋武（郭晋东饰）在带领众人逃生途中遇雪山巨狼追击，患有自闭症的女儿静雯（刘一涵饰）被巨狼掳走成为人质。为解救女儿，他决定勇闯狼穴与变异巨狼展开生死之战。食人狼群步步紧逼，同伴接连沦为“狼口美餐”，巨狼围攻、雪山求生，多重威胁不断升级，一场人与灾难、巨兽之间惊心动魄的较量就此展开。面对这场生死考验众人能否逃出生天？力量悬殊的人兽对战最终谁输谁赢？